Medicinal Chemistry – Lead Identification
The Medicinal Chemistry – Lead Identification unit will take on, explore, and optimize molecules in drug discovery projects. Synthetic and computational chemistry will be at the core of the so-called Design-Make-Test-Analyze cycle that characterizes a small molecule drug discovery program. The mission is to deliver small drug-like molecules with potency, selectivity, physicochemical and ADMET properties of sufficient quality to allow proof-of-concept animal studies. We work in close collaboration with our colleges in the hit-to lead unit.
A technology development program on DNA-encoded libraries was initiated in 2018. A dedicated instrument park with a LC-MS for analysis of DNA-conjugated molecules as well as a preparatory LC and a gel electrophoresis system is available. The first SciLifeLab DNA-encoded library containing one million compounds is available for smailto:johan.wannberg@scilifelab.uu.seelections. To learn more about the project, contact Johan Wannberg.
Services
- Organic synthesis of bioactive compounds (small molecules and peptides).
- Medicinal chemistry expertize.
- Iterative design, synthesis and analysis of assay data to improve compound properties.
- Compound characterization, structure determination and purity analysis.
- Quantitative structure based activity relationships.
- Scale-up synthesis of bioactive compounds.
- Selection and purchase of commercial compounds.
- Synthesis of reference compounds.
- Competitive Intelligence
- In collaboration with Medicinal chemistry Hit2Lead: Computer-based drug design
Equipment
- Analytical UHPLC-MS.
- Automated flash chromatography systems.
- GCMS instruments.
- Hardware and software for Computer-Aided Drug Design.
- Microwave batch reactors.
- Microwave continuous flow reactors.
- NMR spectrometers.
- Peptide synthesizer.
- Preparative HPLC instruments.
Using the unit
Please contact the Head of Unit, Ulrika Yngve.
Mailing Address
Uppsala University
SciLifeLab, BMC
Medicinal Chemistry – Lead Identification
Box 574
751 23 UPPSALA
Visiting Address/Deliveries
Uppsala University
SciLifeLab, BMC
Medicinal Chemistry – Lead Identification
Husargatan 3
751 23 Uppsala