Daniel Globisch

Daniel Globisch

Key publications

W. Lin, L. Gerullat, P.R. Braadland, A. Fournier, J.R. Hov, D. Globisch
Rapid and Bifunctional Chemoselective Metabolome Analysis of Liver Disease Plasma Using the Reagent 4-Nitrophenyl-2H-azirine
Angew. Chem. Int. Ed. 2024, 63, e202318579. Cover Art

L. Cheng+, M.S.P. Correia+, S.M. Higdon, F. Romero Garcia, I. Tsiara, E. Joffré, Å. Sjöling, F. Boulund, E.J. Norin, L. Engstrand, D. Globisch*, J. Du*
The protective role of commensal gut microbes and their metabolites against bacterial pathogens
Gut Microbes 2024, 16, 2356275.

A. Kaur, W. Lin, V. Dovhalyuk, L. Driutti, M.L. Di Martino, M. Vujasinovic, J.-M. Löhr, M. Sellin, D. Globisch
Chemoselective bicyclobutane-based mass spectrometric detection of biological thiols uncovers human and bacterial metabolites
Chem. Sci. 2023, 14, 5291-5301. Cover Art

W. Lin, L.P. Conway, M. Vujasinovic, J.-M. Löhr, D. Globisch
Chemoselective and highly sensitive quantification of gut microbiome and human metabolites
Angew. Chem. Int. Ed. 2021, 60, 23232-23240.

L. P. Conway+, V. Rendo+, M.S.P. Correia, I.A. Bergdahl, T. Sjöblom*, D. Globisch*
Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N‐Acetyltransferase NAT2
Angew. Chem. Int. Ed. 2020, 59, 14342-14346.

C. Ballet⁺, M. S. P. Correia⁺, L. P. Conway, T. L. Locher, L. C. Lehmann, N. Garg, M. Vujasinovic, S. Deindl, J.-M. Löhr, D. Globisch
New enzymatic and mass spectrometric methodology for the selective investigation of gut microbiota-derived metabolites
Chem. Sci. 2018, 9, 6233-6239.

Daniel Globisch

Research Interests

The Globisch lab is an international research group with a focus on the development of new Chemical Biology-based methodologies to improve the analysis of small molecule metabolites in biological samples. These new methodologies are aimed at enhancing the scope of metabolomics-based research. In our multidisciplinary research we work at the interface of Chemistry and Biology with a combination of Organic Chemistry, Chemical Biology techniques, Biochemistry, mass spectrometric analysis of metabolites, and metabolomics. The discovery of specific early-stage biomarkers, new drug targets and the development of new therapeutic interventions are crucial for disease prevention and management towards personalized medicine.

Biomarker Discovery is a challenging and multidisciplinary task. We are developing new tools for mass spectrometric analysis and are focussed on elucidating microbiota metabolism in the human host towards the discovery of unknown bioactive metabolites. We investigate any human sample type, e.g. fecal, urine, and plasma samples from pancreatic cancer patients, colorectal cancer, gut-brain axis, and other common diseases.

Group members

  • Daniel Globisch, Professor
  • Ioanna Tsiara, PhD student
  • Vladyslav Dovhalyuk, PhD student
  • Wawrzyniec Haberek, PhD student
  • Leo Martin, PhD student
  • Carina de Souza Anselmo, postdoctoral researcher
  • Fan Yang, postdoctoral researcher
  • Alejandro Torregrosa Chinillach, postdoctoral researcher
  • ​​Maria Theodorou, Erasmus+ exchange student
  • Kassiani Banava, Erasmus+ exchange student
  • Maris Põdersalu, Master’s student (EACH Program)
  • Adrián Geordi González García, Master’s student (EACH Program)
  • ​​Alberto Iglesias Alonso, Erasmus+ exchange student

Contact

Daniel.Globisch@scilifelab.uu.se

Last updated: 2025-02-12

Content Responsible: admin(website@scilifelab.se)