Adam Ameur is associate professor in genomics and bioinformatics. His work is focused on development of technology and infrastructure, with the aim to improve our knowledge about the human genome and to improve the diagnostics of disease. During the last decade, AA has become a leading expert in long-read sequencing technology and its applications in medical genetics. He is also leading the effort to construct a whole genome data resource of genetic variation for the Swedish population.
Adam Ameur
Uppsala University
Key publications
A national long-read sequencing study on chromosomal rearrangements uncovers hidden complexities.
Eisfeldt J, Ameur A, Lenner F, Ten Berk de Boer E, Ek M, Wincent J, Vaz R, Ottosson J, Jonson T, Ivarsson S, Thunström S, Topa A, Stenberg S, Rohlin A, Sandestig A, Nordling M, Palmebäck P, Burstedt M, Nordin F, Stattin EL, Sobol M, Baliakas P, Bondeson ML, Höijer I, Saether KB, Lovmar L, Ehrencrona H, Melin M, Feuk L, Lindstrand A.
Genome Res. 2024 Nov 20;34(11):1774-1784
Long-read whole-genome analysis of human single cells.
Hård J, Mold JE, Eisfeldt J, Tellgren-Roth C, Häggqvist S, Bunikis I, Contreras-Lopez O, Chin CS, Nordlund J, Rubin CJ, Feuk L, Michaëlsson J, Ameur A.
Nat Commun. 2023 Aug 24;14(1):5164.
CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations.
Höijer I, Emmanouilidou, A, Östlund R, van Schendel R, Bozorgpana S, Tijsterman M, Feuk L, Gyllensten U, den Hoed M, Ameur A.
Nat Commun. 2022 Feb 2;13(1):627.
Amplification-free long-read sequencing reveals unforeseen CRISPR-Cas9 off-target activity.
Höijer I, Johansson J, Gudmundsson S, Chin CS, Bunikis I, Häggqvist S, Emmanouilidou A, Wilbe M, den Hoed M, Bondeson ML, Feuk L, Gyllensten U, Ameur A.
Genome Biol. 2020 Dec 1;21(1):290.
Single molecule real-time (SMRT) sequencing comes of age: applications and utilities for medical diagnostics.
Ardui S, Ameur A, Vermeesch JR, Hestand MS.
Nucleic Acids Res. 2018 Mar 16;46(5):2159-2168.
SweGen: A whole-genome data resource of genetic variability in a cross-section of the Swedish population.
Ameur A, Dahlberg J, Olason P, Vezzi F, Karlsson R, Martin M, Viklund J, Kusalananda Kähäri A, Lundin P, Che H, Thutkawkorapin J, Eisfeldt J, Lampa S, Dahlberg M, Hagberg J, Jareborg N, Liljedahl U, Jonasson I, Johansson Å , Feuk L, Lundeberg J, Syvänen AC, Lundin S, Nilsson D, Nystedt B, Magnusson P, Gyllensten U.
Eur J Hum Genet. 2017 Nov;25(11):1253-1260.