Call for proposals: Chemical Biology and Genome Engineering platform pipeline projects
Chemical Biology and Genome Engineering (CBGE) is a SciLifeLab Infrastructure platform with the mission to turn phenotypic observation into mechanistic insight through a multidisciplinary approach combining chemical, proteomic, and genetic technologies. The platform consists of three units:
Purpose of the call
This call is intended for projects with a clearly defined need for services from more than one unit of the CBGE platform. The purpose is to investigate the mechanism-of-action and/or molecular targets of small molecules identified in activities such as phenotypic assays or other screening efforts. Projects aimed at understanding the mechanism of existing drugs, or projects in drug repositioning and drug repurposing are equally suitable. Other modalities can be considered.
Platform services relevant to this call include, but are not limited to:
Chemical Biology Consortium Sweden (CBCS)
Assays to remove false positives (unspecific redox phenotypes, phopholipidosis), in silico profiling to assess pan-assay interference, database and literature searches, target predictions, establishing structure-activity relationships, synthesis of chemical tools and probes for affinity profiling, compound profiling for toxicity, selectivity or viability, and morphological profiling by cell painting. http://www.cbcs.se/
CRISPR Functional Genomics (CFG)
CRISPR technology for genome-wide or custom pooled loss- and gain-of-function screens, as well as precision editing in cell lines for model system generation and for target validation. https://www.scilifelab.se/units/crispr-functional-genomics/
Chemical Proteomics (Chem Prot)
Proteome wide deconvolution of targets and mechanism-of-action elucidation by methods such as proteome integral solubility alteration (PISA) assay, redox proteomics, FITExP, as well as HDX-MS for binding site mapping. https://www.scilifelab.se/units/chemical-proteomics/
Eligibility and application process
Research group leaders at any Swedish university are eligible to apply. Approved projects will gain cost effective access to CBGE’s cutting-edge technologies.
The deadline for this call is 11/10/2024 at 14.00. We request a demonstration of technical feasibility, so please ensure that you contact CBGE well in advance (and no later than 2 weeks before) the final deadline. Contact anna-lena.gustavsson@scilifelab.se (Platform Director, Head of CBCS) or bernhard.schmierer@scilifelab.se (Platform co-Director, Head of CFG) to request a mandatory meeting.
The application word template available in Anubis (https://anubis.scilifelab.se/) must be used. Finalized project proposals are uploaded directly as a single pdf file into Anubis to the open call for “CBGEPPP24”.
All material provided is considered confidential, and access is restricted to a limited group of CBGE personnel under conditions of confidentiality, solely for the purpose of evaluating the proposed research.
Contact details
Information about this call and CBCS services: Anna-Lena Gustavsson (Platform Director, Head of CBCS) – anna-lena.gustavsson@scilifelab.se
CFG services: Bernhard Schmierer (Platform-co-Director and Head of CFG) – bernhard.schmierer@scilifelab.se
Chemical Proteomics services: Massimiliano Gaetani (Head of ChemProt) – massimiliano.gaetani@ki.se
Upcoming webinar
Together with the SciLifeLab Drug Discovery & Development platform, the Chemical Biology & Genome Engineering platform and the unit for Chemical Biology Consortium Sweden (CBCS) will hold a webinar on August 15th to inform about the available calls for project support, and clarify which call is best suited for your project. Proposals in all areas of biology welcome, not only in human health.
