Extracellular vesicles in cancer therapy-role of checkpoint molecules
April 8, 2024 @ 15:15 – 16:15 CEST
Susanne Gabrielsson
Professor
Karolinska Institutet
Bio
Prof. Gabrielsson has after her PhD at Stockholm University and a postdoc at the Curie Institute in Paris, established a group dedicated to extracellular vesicle (EV)/exosome research at the Karolinska Institutet. She has been a pioneer in the field of immune effects of exosomes. Dr. Gabrielsson was the first to describe the presence of exosomes in bronchoalveolar lavage fluid, as well as in breast milk. Her work has revealed that EVs are major players in lung diseases such as asthma and sarcoidosis, where they contribute to inflammation. Her studies in animal models give new insights into how EV based therapies can be optimized for immunotherapeutic applications in cancer.
Extracellular vesicles in cancer therapy-role of checkpoint molecules
The talk will focus on their work to use EVs for cancer therapy. They lately showed that EVs can induce response to checkpoint inhibitors in a treatment refractory model (Veerman et al, 2023), and they are now investigating the role of PD-1 and PD-L1 on EVs by investigating immune responses to EVs from PD-1 and PD-L1 KO mice.
Host: Masood Kamali-Moghaddam masood.kamali@igp.uu.se, UU
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