[The Svedberg seminar] – Photo-“click” and photo-“unclick” strategies for spatiotemporal control of substrate immobilization and release
May 22 @ 15:15 – 16:15 CEST
Vladimir Popik , Professor of Chemistry
University of Georgia, USA
Bio
Vladimir Popik received his MSc degree (Chemistry) from the Leningrad State University (1986, Leningrad, USSR). His PhD project “Conformational Structure and Photochemical Reactivity of 1,3-Diazodicarbonyl Compounds” was under the supervision of Prof. Irina Korobitcina and Valery Nikolaev at St. Petersburg State University (same school, new name). After defending his PhD dissertation in 1990, he continued as a Research Scientist. In 1992 joined Prof. A. Jerry Kresge group at the University of Toronto as a postdoc then accepted Visiting Research Professor position at the University of Toronto in 1996. In 1999 Valdimir joined the faculty of the Center for Photochemical Sciences at the Bowling Green State University as an Assistant Professor. In 2005 he was promoted to Associate Professor. In 2006 Vladimir Popik moved to the University of Georgia where he is now Professor of Chemistry.
Awards: NSF Career Award 2004; Georgia Cancer Coalition Distinguished Scholar 2006; Senior Member of the National Academy of Inventors 2022.
Research interests: devlopment of photochemical tools for biochemical, bioimaging, and material sciences applications; practical use of two-photon photochemistry; development of novel strategies for click and photoclick ligations; rational design and synthesis light-activated antimitotic agents and gasotransmitteres; investigation of the mechanism of fast reactions.
120 Peer-reviewed publications, (h-index = 41) , 10 patents.
Photo-“click” and photo-“unclick” strategies for spatiotemporal control of substrate immobilization and release
Photochemical triggering of “click” reactions permits the spatial and temporal control of the derivatization, labelling, cross-linking and patterning of various substrates. The absence of potentially detrimental catalysts and/or activating reagents is another beneficial feature of this approach. “Photo-SPAAC” click strategy is based on the photo-decarbonylation of cyclopropenone moiety incorporated into an 8-membered ring. Induction of photo-“click” ligation using two-photon excitation with NIR light (700 – 800 nm or ~ 1100 nm) allows for the 3-dimensional control of the process.
Photo-cleavable linkers, on the other hand, allow for the spatiotemporal control of the substrate release.
Host: Daniel Fürth, UU furth@scilifelab.uu.se
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