Spotlight seminar – Jon Yewdell
October 22, 2024 @ 15:15 – 16:00 CEST
Speaker: Jonathan Wilson Yewdell
Chief, Cellular Biology Section Laboratory of Viral Diseases
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Health (NIH)
Bethesda, MD, USA
Biography:
Jon Yewdell graduated from Princeton University in 1975 with an AB in biochemistry and received MD and immunology PhD degrees from the University of Pennsylvania in 1981. After a post-doctoral fellowship at Imperial College in London with David Lane, he spent 4 years as an Assistant Professor at the Wistar Institute in Philadelphia. In 1987 he joined NIAID. His lab uses influenza A, SARS-CoV2, vaccinia and other viruses to explore basic elements of cell biology, virology, and immunology, and has contributed to understanding how peptides are generated for CD8+ T cell immunosurveillance.
Title: Drips and SliPS and Retirees, Oh My!
Abstract for the talk:
MHC class I molecules present short peptides derived from biosynthesized proteins, enabling CD8+ T cell immunosurveillance of tumors, viruses and intracellular microbes. Many cellular peptides, and likely nearly all viral peptides, derive from rapidly degraded proteins, which consist of defective ribosomal products (DRiPs) and short-lived proteins (SLiPs). I will describe the nature of a number of influenza virus DRiPs and how ribosome profiling facilitates the identification of peptides derived from non-canonically translated cellular DRiPs. I will also discuss how cells with ribosomes lacking individual protein subunits demonstrate either enhanced or decreased peptide generation in a subunit-specific manner and how this can be exploited by cancer cells to escape immunosurveillance. I will present a model to explain how peptide generation avoids the law of mass action to generate a highly diverse peptide repertoire (immunopeptidome) that enables pathogen and tumor recognition. This talk will illustrate how, in over 4 decades of research, cell biology, virology, and immunology can be combined to dissect a medically important immune effector mechanism.
Host: Adnane Achour, adnane.achour@scilifelab.se
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