Discovery of SARS-CoV-2 Main Protease inhibitors at the DDD platform
Pandemic preparedness and the generation of SARS-CoV-2 inhibitors – A new exit from SciLifeLab Drug Discovery and Development platform
DDD Exit Event 2023-11-07, zoomcast 13.00
Presenters
Dr. Ulf Ribacke. Dept. of Microbiology, Tumor and Cell Biology, Karolinska Institutet
Tel: +46 70 497 5196, Email: ulf.ribacke@ki.se
Prof. Jens Carlsson, Dept. of Cell and Molecular Biology, Uppsala University
Tel: +46 72 227 7976, Email: jens.carlsson@icm.uu.se
Abstract
SciLifeLab has been commissioned by the government to build laboratory capacity to assist in future pandemics through research and competence and technology development. Hear more about the SciLifeLab Pandemic Laboratory Preparedness program from Ulf Ribacke, (SciLifeLab and Karolinska Institutet) and groundbreaking research performed by researchers at Uppsala University that led to discovery of potent main protease SARS-CoV-2 inhibitors.
Jens Carlsson, Helena Danielson, Anja Sandström and Lindon Moodie have recently signed an agreement for international partnering of a project focusing on development of drugs for treatment of COVID-19 (DP_JC_188).
The project was funded by the National COVID-19 Research Program initiated by the Knut and Alice Wallenberg Foundation. Hit compounds identified by virtual screening were published in 2022 by Luttens et al. (https://doi.org/10.1021/jacs.1c08402). Hit-to-lead generation was then performed together with the Drug Discovery and Development Platform in the DP_JC_188 project. Lead optimization and preclinical development of assets are now supported by an international pharmaceutical company.
Short speakers biography:
Ulf Ribacke: Ulf is scientific co-director of the SciLifeLab Pandemic Laboratory Preparedness program and heads two research labs located at Karolinska Institutet and Uppsala University, both dedicated to resolve how malaria parasites adapt to evade cellular stress with the ultimate goal to identify targets for new interventions.
Jens Carlsson: Jens is a Professor of Computational Biochemistry at Uppsala University, where his group uses computational models to understand protein function at the molecular level and develops strategies for drug discovery.
For more information, visit http://www.carlssonlab.org/.
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