DDLS Bioinformatics Support

The Bioinformatics Long-Term Support at SciLifeLab strives to enable excellent and Data-Driven Life Science, by ensuring that peer-reviewed research projects have access to advanced bioinformatics and data science competence, and by providing knowledge transfer and broad community training. The bioinformatics support staff is also strongly promoting and applying Reproducible Research, Open Science and FAIR data handling. 

Applications will be reviewed three times a year, with application deadlines typically in January, May and October.

NEW! Cryo-EM/structural biology support

As of 2023, DDLS bioinformatics support also offers computational expertise for structural biology projects involving Cryo-EM and Cryo-ET data, potentially combined with other structural biology and structure prediction methods.
Please use the link above.

Curious about what we work on? Please see our project list.

About bioinformatics support at SciLifeLab

The Bioinformatics Long-term Support at SciLifeLab is operated by the SciLifeLab bioinformatics platform (NBIS) and offers extensive bioinformatics support to a limited set of scientifically outstanding projects. This support has been enabled primarily by a generous grant from Knut and Alice Wallenberg Foundation (KAW) and through the Data-Driven Life Science program. The idea is simple: A senior bioinformatician will work on your project for 500 hours for free! Hands-on involvement by the applying research group is required to ensure efficient knowledge transfer.

The Long-Term Support team has internationally competitive expert knowledge in large-scale molecular data analyses and data science. The staff are experts in genomics, transcriptomics, proteomics, epigenetics, metagenomics, metabolomics, single-cell analyses, multi-omics integration and AI/Machine Learning applications, and our joint experience spans across many types of organisms and include projects from both medical, ecological and evolutionary research across all the four Research Areas of the DDLS program. More information about the all types of bioinformatics project support offered by DDLS and SciLifeLab including application and selection criteria for the Long-term Support is found at the NBIS Bioinformatics Support pages.

In addition, all Bioinformatics support staff are also heavily engaged in community training, for example through the SciLifeLab courses and the DDLS training program. The bioinformatics support staff also aim to take a leading role in implementing Reproducible Research, Open Science and FAIR data, working closely with the NBIS Data Management team and the SciLifeLab Data Platform.

Approved projects 2024

Project title	Applicant	Organization
The structure of oligomers of the amyloid-β peptide	Andreas Barth	SU
Ultrastructure of nature’s high performance fiber and novel bioactive hydrogels	Anna Rising	SLU
Single cell landscape of immune responses in the upper respiratory tract of patients with influenza virus infection.	Anna Smed Sörensen	KI
Binding mechanism of the chaperone BRICHOS to α-synuclein fibrils	Axel Abelein	KI
Profiling of histone modifications in type 2 diabetes	Charlotte Ling	LU
Understanding abundance patterns in Amazonia	Christine Bacon	GU
Multiomics analysis of patient-derived pancreatic tumor organoid lines	Daniel Öhlund	UmU
Genetical Genomics and Causation Analysis using Single Cell data	Dominic Wright	LiU
Prediction of Prophage-related Injection Machines and Unseen Features	Eva Maria Rebrova	LU
Folding a small, superstable protein within the ribosome	Gunnar von Heijne	SU
Structural characterization of the leukotriene biosynthetic complex	Jesper Haeggström	KI
Experimental evolution of dosage compensation	Jessica Abbott	LU
Studies of the microbiome in cancer	Joakim Dillner	KI
Exploring the role of transposable elements in human brain evolution	Johan Jakobsson	LU
Structural basis for potent henipavirus neutralization	Leo Hanke	KI
Bacterial gene expression and host response during pneumonia	Magnus Paulsson	LU
The genes and pathways of pain, analysis of sensory neurons diversity	Marcin Szczot	LiU
De-novo genome annotation of the ball-rolling dung beetle, Kheper lamarcki	Marie Dacke	LU
Hypervariable loop length of combinatorial library-derived antibodies	Mats Ohlin	LU
How do somatic mutations contribute to ageing?	Matthew Webster	UU
Population genomics of wildlife malaria across a quarter of a century	Olof Hellgren	LU
Identifying secreted proteins and mechanisms in enteroendocrine cells	Olov Andersson	UU
Cryo-EM studies of the toxin-associated P47 from P. bifermentans.	Pål Stenmark	SU
Identify drug binding on the eukaryotic ribosome	Robin Fåhraeus	UmU
Developing a deep learning approach to fully integrate contextual information from remote sensing for species distribution modeling	Tobias Andermann	UU
The importance of structural variation in early domestication	Torsten Günther	UU
Spatial gene enrichment analysis with permutation testing	Tuuli Lappalainen	KTH
Spatio-temporal regulation of the developing enteric nervous system	Ulrika Marklund	KI
Photosynthetic regulation under high light stress	Wolfgang P Schröder	UmU

Older projects

DDLS Data Science Nodes

The principles of the DDLS Bioinformatics support is described here.