Infrastructure services
Find contact details to all our Units here
Infrastructure Units
ADME of Therapeutics
UDOPP is the DDD-platform unit for absorption, distribution, metabolism, excretion (ADME) and pharmaceutical profiling.
Affinity Proteomics
The Autoimmunity Profiling and Affinity Proteomics units at SciLifeLab both specialize in proteomics but serve distinct research needs.
AIDA Data Hub
The AIDA Data Hub offers Data Sharing, Policy, Support, and Services for the Swedish medical imaging diagnostics AI research and innovation community. The purpose is to gather, annotate, and share large volumes of data necessary in order to enable research, innovation and clinical adoption of world-class AI technology. We also operate a GPU compute system for AI training on sensitive personal data for Swedish researchers.
Ancient DNA
Use cleanroom labs and specialized molecular genetics techniques to extract, make libraries, sequence and analyze DNA in ancient and/or degraded biological material.
Biochemical and Cellular Assay
The Biochemical and Cellular Assay unit provide the drug discovery projects in the DDD platform with enzymatic and cellular assays using microplate based technologies. We support the drug discovery projects with analyze of the activity for newly synthesized molecules and biologicals in order to drive structure-activity explorations and thereby enabling the next round of design of a new molecular entities.
BioImage Informatics
The BioImage Informatics Unit provides the support and training you need to perform state-of-the-art analyses on your image data. Whether you are looking for training on how to use existing software solutions or help developing a custom workflow, you can get support from us.
Biophysical Screening and Characterization
The unit provides in depth information on interactions.
Chemical Biology Consortium Sweden
To explore complex biology, CBCS provides expertise and support in assay development, screening & chemistry to generate small molecules for applications in all life science research areas.
Chemical Proteomics
The Chemical Proteomics unit (ChemProt) is a national unit expert on supporting drug discovery and development by proteome-wide deconvolution of targets and action mechanisms of small molecules.
Clinical Genomics
Develops and provides clinical genetic tests using state-of-the-art genomic methods, such as next-generation sequencing, for translational research and healthcare.
Clinical Genomics Göteborg
Clinical Genomics Göteborg was established in January 2016 as a collaborative effort between the Sahlgrenska Academy at the University of Gothenburg and Area 4, Laboratory Medicine at the Sahlgrenska University Hospital. Its aim is to facilitate translational research and help bridge the gap from research to clinical routine. Our sequencing and bioinformatics units are closely associated, providing an end-to-end solution from sample to analysis. Translational research projects are carried out in close collaboration with both researchers and clinicians, locally and nationally.
Clinical Genomics Linköping
Clinical Genomics Linköping was established in 2019 as a regional distributed node of the Diagnostic and Development platform of SciLifeLab and the section of molecular genetics at the Linköping University Core unit. CG Linköping is organized at the medical faculty and operates in close collaboration with the clinical NGS platform at the University hospital in Linköping forming the local Genomic Medicine Sweden node GMC-south east.
Clinical Genomics Lund
Clinical Genomics Lund was established in 2016 as a joint strategic initiative between the Medical Faculty at Lund University and the Division of Laboratory Medicine, Medical Services, Region Skåne. The unit encompasses two centers, Center for Translational Genomics (CTG) and Center for Molecular Diagnostics (CMD) that are fully aligned and operate in tight synergy, but with separate responsible bodies and budgets (Lund University and Region Skåne, respectively). Clinical Genomics Lund aims to provide state-of-the-art next generation sequencing (NGS)-based services to strong and high-profile translational research projects and to implement new NGS-based tests for clinical diagnostics within the healthcare system aiming at broader national coverage and consensus.
Clinical Genomics Stockholm
The Clinical Genomics Stockholm unit is a research infrastructure at Science for Life Laboratory (SciLifeLab) for large-scale, genomics-based analyses using next generation sequencing technologies. The unit assists in translational research projects, in the translation of genomics-based tools to routine clinical care and also aims to improve the capability for national microbial surveillance and for pandemic preparedness.
Clinical Genomics Umeå
Clinical Genomics Umeå is a joint venture between Umeå University and the clinical laboratories at Umeå University Hospital. It operates in a tight collaboration with Genomic Medicine Center North and is an integrated part of the Department of Medical Biosciences, Umeå University.
Clinical Genomics Uppsala
Clinical Genomics Uppsala is jointly set up by Uppsala University, Uppsala University Hospital and SciLifeLab with the aim to catalyze the transition of novel research findings into molecular diagnostics for clinical use. The unit is fully integrated within the Uppsala University Hospital and has extensive experience in development and implementation of state-of-the-art next-generation sequencing (NGS) technology in routine diagnostics. We take on research and development projects with a clear translational profile. With our team of associated geneticists, bioinformaticians and medical doctors, we can deliver clinical assessments of the detected variants with the aim to truly provide bench-to-bedside service.
Clinical Genomics Örebro
Clinical Genomics Örebro was established in 2019 as a collaborative effort between the Department of Laboratory Medicine and the Clinical Research Laboratory (KFL) at Örebro University Hospital together with Örebro University.
CRISPR Functional Genomics
Pooled high-throughput CRISPR-Cas9 perturbation for genetic loss- and gain-of-function screens.
Cryo-EM
The Cryo-EM Swedish Infrastructure Unit offers access to state-of-the-art equipment and expertise in single particle cryo-EM and cryo-tomography (cryo-ET).
Display and Selection Technologies
The Display & Selection Technologies unit supports the development of therapeutic antibodies and single domain antibodies. The unit will assist by isolating human antibodies from in-house constructed IP free phage libraries towards target proteins as suggested by the partner PI. It will be of critical importance that the partner PI has substantial knowledge and know-how of the target protein/biological system, either from a clinical or basic scientific perspective. The objective is to deliver a reasonable number of candidate clones for further in vivo characterization in collaboration with the partner PI.
Drug Discovery and Development Platform (DDD)
Generates small-molecule, antibody and oligonucleotide leads for further progression into therapeutic applications and support with target product profiling and safety assessment of the future drug
Exposomics
The National Facility for Exposomics at SciLifeLab (Campus Solna) is coordinated by Stockholm University and the Department of Environmental Science (ACES). With expertise in small molecule mass spectrometry in human and environmental samples [1-4], we operate as infrastructure within the bigger SciLifeLab Metabolomics & Exposomics Platform.
In Situ Sequencing
The in situ sequencing (ISS) unit provides spatially resolved gene expression data for panels of genes at subcellular resolution. The technique has been developed in the lab of Mats Nilsson who has pioneered the field of generating in situ gene expression and mutation profiles (Ke R et al; 2013 Nature Methods).
Integrated Microscopy Technologies (IMT)
Support advanced light microscopy (ALM), electron microscopy (FIB-SEM) and correlative array tomography (CAT) projects
Medicinal Chemistry – Hit2Lead
The Medicinal Chemistry – Hit2Lead unit identifies promising early small molecule leads for further optimization.
Medicinal Chemistry – Lead Identification
The Medicinal Chemistry – Lead Identification unit will take on, explore, and optimize molecules in drug discovery projects.
MS-based Metabolomics: Swedish Metabolomics Centre & Chalmers Mass Spectrometry Infrastructure
The Swedish Metabolomics Centre and the Chalmers Mass Spectrometry Infrastructure at SciLifeLab both specialize in MS-based metabolomics and lipidomics, but serve distinct research needs.
MS-based Protein Analysis: Global Proteomics and Proteogenomics, & Glycoproteomics and MS Proteomics
The Global Proteomics and Proteogenomics unit at SciLifeLab in Stockholm (at Karolinska Institutet) and the Glycoproteomics and MS Proteomics unit at SciLifeLab in Gothenburg (at Gothenburg University) both specialize in MS-based protein and peptide analysis using cutting-edge technologies. We welcome all areas in medicine, natural sciences, planetary biology and all other biology disciplines.
National Bioinformatics Infrastructure Sweden (NBIS)
Provides custom-tailored support with data analysis, computational tools, systems development and training.
National Genomics Infrastructure (NGI)
The National Genomics Infrastructure (NGI) provides services for next generation sequencing and SNP genotyping on all scales using a comprehensive range of modern technology
OligoNova Biology
OligoNova offers state-of-the-art drug discovery infrastructure and expertise to researchers and supports the translation of fundamental research findings into patient-benefitting therapeutic molecules. OligoNova Biology primarily provides bioinformatics and hands-on assays required to progress the oligonucleotide drug discovery and development programs, but can also provide services to academic and external researchers.
Spatial Mass Spectrometry
Spatial mass spectrometry is a label-free method that allows for the visualization and quantitative analysis of the distribution of targeted or untargeted chemical species directly in tissue sections. We utilize advanced mass spectrometry imaging (MSI) instruments and ionization methods, i.e., matrix-assisted laser desorption ionization (MALDI) and desorption electrospray ionization (DESI). The speed, sensitivity, and molecular specificity of the mass spectrometers enable the direct and simultaneous imaging of hundreds to thousands of molecules (in each pixel). The Spatial Mass Spectrometry unit provides a service for the imaging of drugs, their metabolites and endogenous biomolecules such as neurotransmitter systems, lipids, glycans, peptides, and small proteins directly in tissue sections at near-cellular lateral resolution.
Spatial omics
Provides services for a variety of tools for spatially resolved molecular profiling in tissue sections for both gene and protein expression.
Spatial Proteomics
Has a unique and near proteome wide collection of polyclonal antibodies. These reagents can be applied in your research project to perform targeted proteomics in cell lines and tissue sections.
Spatial Transcriptomics
Spatial Transcriptomics is a method that allows visualization and quantitative analysis of the transcriptome in individual tissue sections
Structural Proteomics
The Structural Proteomics infrastructure unit provides access to cutting-edge equipment and expertise, for analysis of protein interactions and conformational dynamics with mass spectrometry.
Support for Computational Resources
The Support for Computational Resources unit works to improve the productivity of life science researchers using nationally available compute and storage resources, especially the NAISS-funded systems at UPPMAX. By providing a ready environment for life science data analysis on powerful compute resources, SCoRe makes these resources more accessible to a wider range of researchers. Our goal is that all scientists that could benefit from large-scale compute and storage systems can do so with minimal effort and maximum scientific output.
Swedish NMR Centre
Provide structure determination and dynamic characterization of proteins including their interactions with ligands and other biomolecules.
Target Product Profiling & Drug Safety Assessment
This unit gives support to principal investigators and innovation agencies in preparing a first target product profile, assists with platform and project coordination, and gives assessment of target dependent toxicity and support with the design of pharmacological studies in vivo.
Therapeutic Protein Engineering
The Protein Expression and Characterization unit provides recombinant proteins needed for biochemical screening and therapeutic applications as well as antigens for human antibody production using bacterial and mammalian expression systems.