Bioinformatician, OligoNova Hub

Ref PAR 2022/554

The University of Gothenburg tackles society’s challenges with diverse knowledge. 56 000 students and 6 600 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

OligoNova Hub is a national research infrastructure that provides academic researchers in Sweden with support and capabilities to transform ideas and discoveries into new oligonucleotide therapies. The Hub is located within the vibrant biotech cluster at the AstraZeneca BioVentureHub in Mölndal. OligoNova Hub is organized within the Core Facilities at the University of Gothenburg (www.cf.gu.se), and is also part of the Science for Life Laboratory Drug Discovery and Development platform (https://www.scilifelab.se/units/ddd-platform/ ), a national resource comprising 50+ scientists with complementary expertise in drug discovery.

The position will be connected to the Sahlgrenska Academy Bioinformatics Core Facility, which currently employs 9 experts and provides a wide range of statistical and bioinformatics analysis to academic and non-academic users. For more information, see www.bioinformatics.cf.gu.se.

Duties

As Bioinformatician at the OligoNova Hub, you will be responsible for design of therapeutic oligonucleotides and analysis of their biological effects. You will be a key partner in the drug development team, working with our experts in biology and oligonucleotide chemistry. You will also collaborate closely with the Bioinformatics Core Facility in the data analysis of innovative oligonucleotides and their biological effects.

In your role you will be using bioinformatics approaches and machine learning to identify and deliver oligonucleotide sequence designs. You will be responsible for developing and implementing appropriate algorithms, techniques and datasets for the discovery of oligonucleotide candidate drugs. You will complement and coordinate data analysis capabilities in the identification of biological induced effects of the oligonucleotides by analyzing, integrating and interpreting multiple modalities of omics data. You will also contribute to RNAseq analyses for the different oligonucleotide projects to ensure that the results are scientifically robust and well documented.

Qualifications

• You must have a PhD in Bioinformatics, Statistics, Computer Science or equivalent.
• You must be experienced in DNA/RNA sequence analysis, NGS data analysis and/or machine learning methods.
• You must be experienced in Unix/Linux and R, as well as with an established scripting language (Python is preferred).
• You should be familiar with git, conda, Snakemake and/or Nextflow.
• Previous experience with oligonucleotide bioinformatics, oligonucleotide/RNA structure prediction, and analysis of mammalian gene expression is a strong merit.
• Previous experience of analyzing disease mechanisms and/or drug discovery related projects is desired.
• Previous experience working in multidisciplinary environments is beneficial.

Great emphasis is placed on personal suitability, good communication and interpersonal skills. You should be able to work independently as well as part of a team. You should be self-motivated and service-minded and have a positive, result-oriented and problem-solving attitude. You should have excellent written and oral communication skills in English.

Employment

The position is a full-time (100%), permanent position, placed at OligoNova Hub, Mölndal, within the Core Facilities, Sahlgrenska Academy, at the University of Gothenburg. A probationary employment period of 6 months may be applied. Starting date as agreed.

Contact information for the post

For further information about the employment please contact Pär Matsson, Scientific Director OligoNova Hub, tel +46 (0) 7661 49 32, par.matsson@gu.se, and Marcela Dávila, Head at the Bioinformatics Core Facility, tel +46 (0)31 786 9717, marcela.davila@gu.se .

Unions

Union representatives at the University of Gothenburg can be found here: https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande

Application

To apply for a position at the University of Gothenburg, you have to create an account in our recruitment system. Submit your application via the University of Gothenburg’s recruitment portal by clicking the “Apply” button. It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline.

Applications must be received by: 2022-05-16

The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.

Salaries are set individually at the University.

In accordance with the National Archives of Sweden’s regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed.

In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.