The workplace
The successful candidate will work at the SciLifeLab, Solna. Science for Life Laboratory (SciLifeLab, www.scilifelab.se/)
SciLifeLab is a national resource center dedicated to large scale bioscientific research with focus on biomedicine, including genome and proteome profiling, bioimaging and bioinformatics. SciLifeLab Stockholm has been formed jointly by the three Stockholm universities, Royal Institute of Technology (KTH), Karolinska Institutet (KI) and Stockholm University (SU), and thus combines the profiles and strengths of these three institutions. Academic research as well as the Swedish health care system and the Swedish Life Science industry will benefit through active collaboration, access to advanced tools and active programs for knowledge transfer. The goal is to achieve critical mass for large-scale life sciences and translational medicine. The post will be in microbiome lab within the division of Systems Biology consisting of research groups focusing on systems biology related research spanning from photosynthetic bacteria, microbial research, human biology, systems medicine, metabolic and network modelling, protein science, antibody engineering and precision medicine and range from basic research in human and microbial biology to more applied research, including clinical applications in cancer, infectious diseases, cardiovascular diseases, autoimmune diseases and neurobiology.
Project description
Metagenomic studies in the human microbiome has enabled the characterization of the microbial and their functional diversity in health and diseases. Advances in metagenome assembling and various clustering methods have enabled the generation of co-abundance gene groups and metagenome species. In the group we work on microbial gene catalogues and generating metagenome species, including bacteria and fungi together with identification of antimicrobial resistance genes to elucidate their mechanisms in health and disease, future microbiome-based therapies and propose new ways to cease the rapid spread of antibiotic resistance in global health.
We are now seeking one postdoc with strong skills to work on cohorts of the human oral and gut microbiome samples to investigate the longitudinal changes of bacterial and viral abundances, resistome, by using and developing different computational techniques to elucidate the key fucntion mechanism of action in resilience of microbiome longitudinally and also contribution to disease pathophysiology. One of the key projects will be on liver diseases and investigating on the intestinal and oral dysbiosis and evaluate the antimicrobial resistance gene. profiles in salivary and faecal metagenomic data in chronic liver disease. This part of the project will be in close collaboration with clinical investigators. The posts will also contribute to the expansion of our recently developed human microbiome atlas and the recent announced one million microbiome project.
Location: Science for Life Laboratory, Solna, Stockholm, Sweden
Contact
For more information, please contact Dr. Saeed Shoaie (saeed.shoaie@scilifelab.se) and Professor Mathias Uhlen (mathias.uhlen@scilifelab.se)
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