Glycomics of Human Immune Responses

Eurolife Distinguished Lecture

Professor Manfred Wuhrer, Leiden University Medical Center

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Welcome to this lecture by Prof Dr Manfred Wuhrer from Leiden University Medical Center, The Netherlands, as part of the Eurolife Distinguished Lecture Series (EDLS).

Glycosylation is a key factor in shaping multicellular life including immunological responses. Glycosylation modifies the activity and fate of both antibodies and immune cells involved in infections, inflammatory responses and cancer. Mass spectrometry approaches allow to unravel disease-associated glycosylation changes including specific glycans attached to the Fc portion of antibodies that dictate antibody effector functions in auto- and alloimmune conditions, inflammatory and infectious diseases, and cancer. Exploring the glycomic dimension of diseases has great promise in providing novel diagnostic and therapeutic leads.

More information about Prof Dr Manfred Wuhrer from Leiden University Medical Center